1 Sustainable Chemicals: A Model for Practical Substitution; Abstract; 1 Introduction; 1.1 Use of Chemicals in Textile Production; 1.1.1 Effect Chemicals; 1.1.2 Processing Chemicals; 1.2 Development of Legal and Voluntary Restrictions of Chemicals Content in Textile Products; 1.2.1 Development of Legal Restrictions Addressing Chemicals in Textiles; 1.2.2 Development of Voluntary Restrictions Addressing Chemicals in Textiles; 1.3 Substitution of Substances, Materials or Products; 1.3.1 Requirements on Alternative Effect Chemicals; 1.3.2 State-of-the-Art Substitution Work 1.4 Life Cycle Perspective2 Model Creation; 2.1 First Development Steps; 2.2 Generalization of the Model; 3 Evaluation via Case Studies; 3.1 The SUPFES Project; 3.1.1 Current Use of Per- and Polyfluoroalkyl Substances (PFAS); 3.1.2 Characterization of Original Substance in Use; 3.1.3 Alternative Selection; 3.1.4 Toxicity and Exposure Assessment; 3.1.5 Case Studies; 3.1.6 Impact and Risk Assessment; 3.1.7 Technical Performance; 3.1.8 Finalizing the SUPFES Project; 3.2 The ENFIRO Project; 3.2.1 Current Use of Flame Retardants; 3.2.2 Prioritization and Selection; 3.2.3 Hazard Exposure 3.2.4 Fire and Application Performance3.2.5 Risk Assessment; 3.2.6 Impact Assessment; 3.2.7 Conclusions from the ENFIRO Project; 4 Evaluation of Interventions; 4.1 SUPFES Evaluation; 4.2 ENFIRO Evaluation; 5 Conclusions; References; 2 Sustainable Wet Processing-An Alternative Source for Detoxifying Supply Chain in Textiles; Abstract; 1 Introduction; 2 Environmental Impact of Wet Processing; 2.1 Importance of Water in Textile Wet Processing; 2.2 Energy Consumption; 2.3 Chemical Utilization; 3 Textile Wet Processing; 3.1 Preparatory Pretreatment; 3.2 Dyeing and Printing Process 3.3 Finishing Process4 Recent Sustainable Development and Innovations in the Wet Processing; 4.1 Eco-friendly Fibers; 4.2 Enzymes; 4.3 Bio-Based Dyeing; 4.4 Plasma Technology; 4.5 Supercritical Fluid Technology; 4.6 Digital Ink-Jet Printing; 4.7 Ultrasonic Waves; 4.8 Innovations in the Machinery; 4.9 Recycling and Reuse of Process Inputs; 4.10 Electrochemical Dyeing; 4.11 Foam Finishing; 5 Detoxifying Supply Chain; 5.1 Supply Chain Management; 5.2 Supply Chain Decision; 5.2.1 Strategic Decision; 5.2.2 Operational Decision; 5.2.3 Tactical Decision 5.3 Challenges and Solutions in Sustainable Wet Processing6 Conclusion; References; 3 Green Dyeing of Cotton- New Strategies to Replace Toxic Metallic Salts; Abstract; 1 Introduction; 2 Plant Extracts; 2.1 Rubia Tinctorum; 2.2 Rubia cordifolia; 2.3 Rubia Sikkimensis; 2.4 Rheum emodi; 3 New Approaches to Replace Toxic Mordants; 4 Conclusion; Acknowledgment; References; 4 Call for Environmental Impact Assessment of Bio-based Dyeing-An Overview; Abstract; 1 Introduction; 2 Life Cycle Assessment; 2.1 Holistic Approach; 2.2 The Four Phases of LCA; 2.2.1 Phase 1: Goal and Scope.